New biological properties of coenzyme, pyrroloquinoline quinone (PQQ)
نویسندگان
چکیده
منابع مشابه
The pyrroloquinoline quinone (PQQ)-containing quinoprotein dehydrogenases.
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Pyrroloquinoline quinone (4, 5-dihydro(4), 5-dioxo(1) H-pyrroloquinoline-2,7, 9 tricarboxylic acid) being a three ortho cyclic quinone substitutes the role of a redox-cofactor for various bacterial dehydrogenases such as methanol, ethanol and glucose dehydrogenases [1-6] also termed as methotaxin [7]. PQQ structure prediction shows that it has been originated from tyrosine and Glutamic-acid [8]...
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Pyrroloquinoline quinone (PQQ), a redox-active o-quinone, is an important nutrient involved in numerous physiological and biochemical processes in mammals. Despite such beneficial functions, the underlying molecular mechanisms remain to be established. In the present study, using PQQ-immobilized Sepharose beads as a probe, we examined the presence of protein(s) that are capable of binding PQQ i...
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One electron reduction of Pyrroloquinoline quinone (PQQ) was studied using pulse radiolysis technique. Reactions of hydrated electron, H atom, radical and superoxide radicals produced very similar transient species. The radicals did not show decay in few milliseconds. The one-electron reduction potential of PQQ was determined at pH 7 using both methyl viologen and benzyl viologen couples and wa...
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A subchronic oral toxicity study on pyrroloquinoline quinone (PQQ) disodium salt was performed in rats. Sprague-Dawley rats were randomly divided into four groups (10 rats/sex/group) and administered with PQQ disodium salt at doses of 0 (control), 100, 200 and 400 mg/kg bw/day by gavage for 13 weeks. Daily clinical observations and weekly measurement of body weights and food consumption were co...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1989
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)56053-x